Group B

AccuProbe® Group B Streptococcus Test

Overview:
Group B Streptococcus (GBS) is one of the leading causes of septicemia and meningitis in newborns. Despite striking declines in the incidence of this disease coinciding with increased prevention activities in the 1990's, GBS disease remains a leading infectious cause of morbidity and mortality among newborns in the United States. To prevent septicemia and meningitis in newborns, the Centers for Disease Control (CDC) recommends universal prenatal screening for Group B strep colonization by vaginal-rectal culture at 35-37 weeks gestation.

Use:
The AccuProbe® Group B Streptococcus Culture ID Test is a rapid DNA probe test which utilizes the techniques of nucleic acid hybridization for the identification of Group B Streptococcus from culture. The test offers a rapid, non-subjective method for the definitive identification of Group B Streptococcus based on the detection of specific ribosomal RNA sequences that are unique to Streptococcus agalactiae.

Features/Benefits:
  • Offers a rapid, non-subjective method of detection
    • Traditional confirmative identification of Group B Strep requires a combination of biochemical and/or serologic tests
    • Sensitivity and specificity, from 18-24 hour Lim broth inocula, comparable to standard culture
    • Detects all serotypes of Group B Step both hemolytic and non-hemolytic
  • Eliminates the need for secondary culture
    • Streamlines workflow
    • Decreases turnaround time
    • Facilitates workflow efficiency by enabling batch testing
References:
  1. MMWR.2002;51:RR-11
  2. Kircher, S.M., M.P. Meyer, and J.A. Jordan. 1996. Comparison of a modified DNA hybridization assay with standard culture enrichment for detecting group B streptococci in obstetric patients. 34:342-344.
  3. Overman, S.B., D.D. Eley, B.E. Jacobs, and J.A. Ribes. 2002. Evaluation of methods to increase the sensitivity and timeliness of detection of Streptococcus agalactiae in pregnant women. 40:4329-4331.
  4. Rosa-Fraile, M., J. Rodriguez-Granger, M. Cueto-Lopez, A. Sampedro, E.B. Gaye, J.M. Haro, and A. Andreu. 1999. Use of Granada medium to detect group B streptococcal colonization in pregnant women. 37:2674-2677.
  5. Bourbeau, P.P., B.J. Heiter, and M. Figdore. 1997. Use of Gen-Probe AccuProbe Group B Streptococcus test to detect group B strep in broth cultures of vaginal-anorectal specimens from pregnant women: comparison with traditional culture method. 35:144-147.
  6. Williams-Bouyer, N., B.S. Reisner, and G.L. Woods. 2000. Comparison of Gen-Probe AccuProbe Group B Streptococcus culture identification test with conventional culture for the detection of Group B streptococci in broth cultures of vaginal-anorectal specimens from pregnant women. 36:159-162.
AccuProbe GROUP A STREPTOCOCCUS Culture Identification Test
Description: For the identification of Group A Streptococcus (Streptococcus pyogenes) isolated from culture.

  PI / MSDS
20 Tests #2925

AccuProbe GROUP B STREPTOCOCCUS Culture Identification Test
Description: For the identification of Group B Streptococcus (Streptococcus agalactiae) isolated from culture.

  PI / MSDS
20 Tests #2820
200 Tests #2820B

Gen-Probe® Detection Reagent Kit Gen-Probe Detection Reagent Kit
Description: Detection reagent used on Leader luminometers for non-APTIMA Gen-Probe assays.

  PI / MSDS
1200 Tests #1791

AccuProbe Culture Identification Reagent Kit AccuProbe Culture Identification Reagent Kit
Description: Reagents for bacterial culture identification tests.

  PI / MSDS
200 Tests #2800


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Gen-Probe Incorporated
10210 Genetic Center Drive
San Diego, CA 92121
USA

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