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The GEN-PROBE HPA technique uses a specific DNA probe, labeled with an acridinium ester detector molecule that emits a chemiluminescent signal.
This DNA probe hybridizes with either the target rRNA in non-amplified tests, or the amplicon produced in the Transcription-Mediated Amplification (TMA) reaction. The solution phase selection/detection step does not require washing. This makes the HPA format as easy to perform as the simplest immunoassays, with the superior specificity of DNA probes. The GEN-PROBE® LEADER® line of luminometers detects and measures the light emitted from the reaction.
Hybridization Protection Assay (HPA) Video
(This animation requires the free Real G2 Player. If you do not have this player, you may download it below.)
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